ACTIVITY INFORMATION
Release Date: March 15, 2007
Expiration Date: October 31, 2008
Activity Code: 09HC04-DE01
Target Audience
This activity is designed for physicians, nurses, and other health care professionals in New Jersey who are involved in the care of persons with HIV/AIDS.
Statement of Need
Antiretroviral therapy for treatment of Human Immunodeficiency Virus type 1 (HIV-1) infection has improved steadily since the advent of combination therapy in 1996. New drugs have been approved, offering added dosing convenience and improved safety profiles, while drawbacks encountered in use of earlier drugs have led to less common use. Despite the widespread availability of the guidelines in print and web format, contraindicated regimens may still be used by providers. This article addresses regimens and combinations to be avoided in HIV treatment, with the goal of improving the quality and appropriateness of antiretroviral treatment.
The Panel on Clinical Practices for Treatment of HIV (the Panel), convened by the Department of Health and Human Services (DHHS), develops and updates guidelines which outline current understanding of how clinicians should use antiretroviral drugs to treat adult and adolescents with HIV infections. The current guidelines include revised recommendations for treatment with evidence of resistance to antiretroviral medication, and summarize preferred regimens vs. combinations that should be avoided. Clinicians who treat patients with HIV infection and AIDS need continuous updates on HIV/AIDS treatment strategies to meet the standards of care set by these guidelines.
REFERENCE: Department of Health and Human Services (DHHS). Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. October 10, 2006 http://aidsinfo.nih.gov
Learning Objectives
Upon completion of this learning activity, the reader should be able to:
- List and describe mechanisms for drug-drug interactions considered contraindicated with HIV medications.
- Identify HIV medications and or regimens that should not be offered to patients at any time due to toxicity issues or due to poor response.
- Classify antiretroviral regimens as preferred, alternative, or not recommended.
Method of Instruction
Participants should read the learning objectives and review the activity in its entirety. After reviewing the material, complete the self-assessment test consisting of a series of multiple-choice and True/ False questions.
Upon completing this activity as designed and achieving a passing score of 70% or more on the self-assessment test, participants will receive a credit letter and the test answer key four (4) weeks after receipt of the self-assessment test, registration, and evaluation materials. Estimated time to complete this activity as designed is 1 hour.
Accreditation
Physicians:
UMDNJ–Center for Continuing and Outreach Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. UMDNJ–Center for Continuing and Outreach Education designates this educational activity for a maximum of 1.0 AMA PRA category 1 creditTM toward the AMA Physician’s Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.
Nurses:
The University of Medicine and Dentistry of New Jersey-Continuing Education and Outreach Education is an approved provider of continuing nursing education by the New Jersey State Nurses Association, Provider Number P173-10/06-09. New Jersey State Nurses Association is accredited by the American Nurses Credentialing Center's Commission on Accreditation.
This activity is awarded 1 contact hour.
UMDNJ-Center for Continuing and Outreach Education is an approved provider of continuing education by the California Board of Registered Nursing, Provider Number CEP 13780 for a maximum of 1 contact hour for this activity.
Review
The activity was prepared in accordance with the ACCME Essentials. This activity was reviewed for relevance, accuracy of content, balance of presentation, and time required for participation by Patricia Kloser, MD, MPH. This activity was reviewed for relevance, accuracy of content, balance of presentation, and time required for participation by Bonnie Abedini, RN, MSN; Mary C. Krug RN, MSN, APN-C; and Debbie Y. Mohammed, MS, APRN-BC, ACRN.
Faculty
John J. Faragon, Pharm.D. is New York/New Jersey AIDS Education and Training Centers – Regional Pharmacy Director, and Pharmacist – Albany Medical College Division of HIV Medicine and Albany Medical Center Department of Pharmacy. Dr. Faragon has presented, taught and been published extensively in his specialty area of HIV Pharmacology, Drug Interactions, and Drug Errors
Disclosure
In accordance with the disclosure policies of UMDNJ and to conform with ACCME and FDA guidelines, all program faculty are required to disclose to the activity participants: 1) the existence of any financial interest or other relationships with the manufacturers of any commercial products/devices, or providers of commercial services, that relate to the content of their presentation/material, or the commercial contributors of this activity, that could be perceived as a real or apparent conflict of interest; and 2) the identification of a commercial product/device that is unlabeled for use or an investigational use of a product/ device not yet approved.
Faculty Disclosure Declarations
Patricia Kloser, MD, MPH (Field Tester and Activity Director) has the following financial relationships to disclose: Speaker’s Bureau: GlaxoSmithKline, Roche;Consultant:Gilead,Boehringer Ingleheim.
The following have no financial relationships to disclose: John J. Faragon, PharmD.; Bonnie Abedini, RN, MSN; Mary C.Krug RN, MSN, APN-C; and Debbie Y.Mohammed, MS, APRN-BC, ACRN.
Off-Label Usage Disclosure
This activity does not contain information
of commercial products/devices that are
unlabeled for use or investigational uses
of products not yet approved.
Disclaimer
The views expressed in this activity are those of the faculty. It should not be inferred or assumed that they are expressing the views of NJDHSS-Division of HIV/AIDS Services, UMDNJ, or any manufacturer of pharmaceuticals. The drug selection and dosage information presented in this activity are believed to be accurate. However, participants are urged to consult the full prescribing information on any agent(s) presented in this activity for recommended dosage, indications, contraindications, warnings, precautions, and adverse effects before prescribing any medication. This is particularly important when a drug is new or infrequently prescribed.
Copyright © 2007 UMDNJ-Center for Continuing & Outreach Education. All rights reserved including translation into other languages. No part of this activity may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval systems, without permission in writing from UMDNJ-Center for Continuing & Outreach Education.
Grantor Acknowledgement
Sponsored by the University of Medicine & Dentistry of New Jersey (UMDNJ), UMDNJ-Center for Continuing & Outreach Education. This activity is supported by an educational grant from NJDHSS Division of HIV/AIDS Services through a MOA titled “Education and Training for Physicians and other Healthcare Professionals in the Diagnosis and Treatment of HIV/AIDS.”
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